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Osteogenesis Imperfecta

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Osteogenesis Imperfecta Types

Since 1979, OI has been classified by type according to a scheme developed by David Sillence,
M.D. This system is based on mode of inheritance, clinical picture, and radiologic appearance.
The OI type descriptions provide some information to the clinician and family about a person’s
prognosis, but they do not predict functional outcome. It is also important to note that the
severity of OI ranges greatly; the different types of OI represent somewhat arbitrary cutoffs
along a continuum. As a result, the severity of the disorder may vary significantly among people
who have the same type. The OI classification scheme has continued to evolve as new
information about OI is discovered.

What is Osteogenesis Imperfecta

What is Osteogenesis Imperfecta? Osteogenesis imperfecta (OI) is a genetic disorder characterized by fragile bones that break easily. It is also known as “brittle bone disease.” A person is born with this disorder and is affected throughout his or her life time. What causes OI OI is caused by an error called a mutation on […]